Effect of fractionated radiotherapy on salivary gland function

Effect of fractionated radiotherapy on the parotid gland: an experimental study in Brazilian minipigs

INTRODUCTION  Radiotherapy (RT) of head and neck neoplasms often damages the salivary glands. AIM  To examine the pattern of morphologic changes resulting from RT of the head and neck region in minipig parotid glands in a clinical and experimental research setting. METHODS  Twelve 18-month-old male Brazilian minipigs weighing 30-40 kg were selected. Eight minipigs were assigned to the exper...

Salivary gland function

p53 function influences the effect of fractionated radiotherapy on glioblastoma tumors.

PURPOSE Glioblastoma multiforme brain tumors (GM) are treated with a spectrum of fractionation regimens based on the clinical and anatomical characteristics of the tumor but rarely based on the molecular characteristics of the individual neoplasm. This study tests the hypothesis that the response of cell lines derived from GM to fractionated radiotherapy depends on the function of wild-type p53...

Radioiodine therapy effects on salivary gland function in patients with differentiated thyroid cancer [Persian]

Salivary gland involvement is one of the radioiodine therapy complications. Salivary gland scintigraphy in quantitative mode can accurately evaluate salivary gland function. Methods: Salivary gland scintigraphy was performed with Tc-99m Pertechnetate, at the time of iodine therapy as a basic study and then 3 weeks and 3 months afterwards. Ejection Fraction (EF) of parotid and submandibula...

Outcome of Surgery and Radiotherapy for Major Salivary Gland Carcinoma

Salivary gland cancers are uncommon malignancies of the head and neck region. Their site of origin can be major (parotid, submandibular and sublingual) or minor salivary gland (palate, nasal cavity, paranasal sinuses, trachea and lacrimal gland). Of all the salivary gland neoplasms, 85% are benign and 15% are malignant. Salivary gland malignancies comprise 3-6% of all head and neck cancers (Pin...